A poor prognostic metastatic nongestational choriocarcinoma of the ovary: a case report and the literature review

Abstract Background Pure ovarian choriocarcinoma can be gestational or nongestational in origin. Nongestational pure is extremely rare and the prognosis thought to worse than that of type patients with metastatic disease. We present a case poor which origin was identified as by DNA short tandem repeat (STR) analysis. Case presentation A nulliparous woman her thirties referred our hospital after initial treatment proved unsuccessful. Two months earlier, she had undergone brain tumor resection histological examination confirmed choriocarcinoma. Serum human chorionic gonadotropin (hCG) concentration at diagnosis 5030 IU/L. cycles combination chemotherapy regimen methotrexate, etoposide, actinomycin-D (MEA therapy), commonly used for choriocarcinoma, administered. However, disease could not controlled. Imaging modalities revealed left ovary lung, but uterus, led us think nongestational. Bleomycin, cisplatin (BEP therapy) (malignant germ cell tumor) surgical bilateral ovaries, an affected part lung nadir level hCG, relapsed levels hCG again increased. To investigate we performed STR analysis cells oral mucosal cells. Analysis nongestational, genotype entirely corresponded BEP therapy regimens administered ineffective, patient died 21 Conclusion Metastaic aggressive disease, frequently resulting outcome.